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Despite the great advances in therapeutics there is still a need to develop safer and more effective methods of delivering drugs to humans and animals. Existing drug delivery systems have been limited in their effectiveness due to poor thermal and chemical stability and by rapid elimination by the immune system.
CeramiSphere's novel technology now offers potential for more effective and efficient therapy including targeted delivery of drugs and other molecules to the precise location in the body where they are needed.
The potential for the pharmaceutical and healthcare industries is significant. Active materials can be formulated into CeramiSpheres that are 'tailor-made' for a specific application. The nature of the carriers is such that far more of the payload is likely to be retained and protected as it passes through the body to the targeted organ. This reduced leakage could mean a reduced risk of side effects, and a higher dose of the active material delivered to the target.
The ability to control the amount of drug delivered over a given time period, could also mean less frequent dosing, with increasing patient compliance and cost savings for both pharmaceutical companies (more efficacious product) and medical insurances (reduced number of visits to medical practitioners)
Preliminary in-vivo experiments reveal enhanced blood stability of the nanoparticles, which, coupled with sustained release of anti-tumour agents, show good potential for cancer treatment.
We are currently planning further work on the development of 'smart' drug delivery systems, by functionalising the CeramiSpheres. These 'stealth particles' will 'home in' on specific cell and organs for which the drugs are intended.
Other important medical applications for CeramiSphere technology include the oral delivery of insulin, the treatment of cancers, wound healing, improved vaccines, transdermal delivery of drugs, and gene therapy.
To date, CeramiSphere research and development has included the manufacturing and testing of sol-gel particles to deliver a wide range of therapeutics (including antibiotics, cytotoxics, anti-histamines, analgesics, proteins, and even DNA).
Nutraceuticals